Dermatology Injections: Botox and Skin Boosters

Understand dermatology injection treatments by dividing them into these 4 categories.

Injection treatments available at dermatology clinics can be broadly divided into the following 4 categories:

1️⃣ Botox

2️⃣ Skin Boosters

3️⃣ Fillers

4️⃣ Contouring Injections

Today, we will focus on summarizing Botox and Skin Boosters.

1️⃣ Botox

① Classification by Purpose

✔ Muscle Botox (For Volume Reduction)

Areas: Square jaw, temporalis, side cheekbone muscles, calf muscles, thigh muscles

Effect Progression

Gradual volume reduction up to 3 months post-treatment

Partial recovery over 4 to 6 months

❗ It does not completely return to its original state

Recommended Interval: At least 6 months

→ It is better to extend the interval with repeated treatments

(Exceptions apply for treating bruxism or strong chewing habits)

✔ Salivary Gland Botox (Volume Reduction Category)

Submandibular gland: Commonly located where a ‘double chin bulge’ appears

Parotid gland: The broad, bulging area in front of and behind the ears

→ Helps refine the volume of the lower face

✔ Wrinkle Botox (For Expression Wrinkles)

Areas: Forehead, glabella (frown lines), around the eyes (crow’s feet), nose bridge, etc.

Interval: 3 to 4 months

* Wrinkle Botox is for wrinkles that appear when making facial expressions (dynamic wrinkles)!

* For static wrinkles visible even when the face is resting

→ It is essential to periodically smooth them out with Botox and combine with lifting and elasticity treatments

✔ Skin Botox

Indications

Fine lines

Neck wrinkles

Pores

Redness

Skin barrier strengthening

V-line lifting assistance

Characteristics

Improves fine lines without making facial expressions look unnatural

Painful but a versatile ‘all-rounder’ with a wide range of applications

Hyperhidrosis Botox (armpits, hands, feet) uses the same method

Recommended Interval: 3 to 6 months

→ Recommended to be combined with lifting and tightening devices

② Types of Botox

Standard Domestic: Hitox, Wondertox, Botulax, Liztox, Nabota, etc.

Premium Domestic: Coretox

Similar to Xeomin

Very low possibility of resistance

Premium Imported: Xeomin

Almost no resistance

③ Botox Resistance

Incidence rate: About 0.1% (Very low)

Cases where the possibility of resistance ↑

Higher dosages

Shorter treatment intervals

Getting Skin Botox too frequently

2️⃣ Skin Boosters

Skin boosters are broadly divided into 3 types:

① PN Regenerative Factors

PDRN, Rejuran, Salmon Injections

② Exosomes (Stem cell-derived ingredients)

ASCE Exosomes

③ Collagen Boosters

Juvelook, Sculptra, Radiesse, Rituo, Cellederm, Retigen, etc.

2-1️⃣ Rejuran

✔ What is Rejuran?

Ingredient: Polynucleotide (Derived from salmon DNA)

Roles

Anti-inflammatory

Wound healing

Skin regeneration

ECM (Extracellular Matrix) environment improvement

✔ Injection Methods

▪ Manual Injection (Wheal method)

Injected stitch by stitch, creating small bumps (embossing)

Can be difficult for those with trypophobia

▪ About Embossing

Rejuran has large particles and high viscosity, making the bumps highly visible

Thin and dry skin → Bumps are very visible

Thick and oily skin → Bumps may barely form

👉 For skin that forms fewer bumps, drug injectors or Potenza pumping tips are more suitable

✔ Device Injection Methods

Derma Shine

Uniform depth and spacing

Potenza Pumping Tip

Microneedling

Less pain and bleeding

Makeup can be applied the next day

Covers pores, scars, texture, and elasticity all at once

👉 Immediate effects may be slower, but long-term regeneration effects are not significantly different from manual injections

In fact, it is sometimes more recommended due to the greater synergy and additional effects from the needles and radiofrequency

✔ Rejuran Effects

Pores

Redness

Skin barrier strengthening

(Recommended as a primary treatment for atopic dermatitis and skin inflammation patients)

Elasticity

Fine line reduction

✔ Types of Rejuran

Rejuran Healer: The Original

Rejuran HB: Lidocaine + HA + PN

Pain ↓ (Less than half compared to Healer)

Moisture ↑

Faster noticeable effects

Rejuran i: Exclusively for the eye and mouth areas

✔ Dosage Guide

Usually 4cc to 6cc for a full face

2-2️⃣ Exosomes

✔ What are Exosomes?

Intercellular signaling substances

Decreases with aging → Leads to reduced regeneration

✔ Roles

Anti-inflammatory

Promotes regeneration

Increases collagen and elastin

Whitening and pigmentation relief

Reduces the frequency of breakouts

👉 Top recommendation for sensitive skin prone to frequent inflammation

❗ However, Exosomes are only approved as cosmetics

→ Direct injection is not allowed