2026-07-03
Rejuran
A comprehensive guide to Rejuran, a PN-based skin booster for regeneration. Learn about injection methods, types like HB and Eye, and expert tips.

2-1) Rejuran Healer

What is Rejuran?
**Rejuran** is a skin booster composed of a single active ingredient: Polynucleotide (PN).
Extracted from salmon DNA, PN exists in our skin’s **Extracellular Matrix (ECM)** and
Provides anti-inflammatory effects
Repairs damaged tissue
Plays a core role in promoting skin regeneration.
In other words, it is not simply an ‘injection that makes your skin look moisturized,’ but
👉 A regenerative treatment that fundamentally transforms your skin into a healthier state.
Rejuran Expert, Dr. Park Yumi

Since 2021, working at a clinic specializing in Rejuran, Thermage, and Skin Botox,
I have been awarded the Rejuran Expert plaque in recognition of my extensive clinical experience and outstanding results.
For Rejuran,
✔️ Injecting as densely as possible
✔️ Creating as many embossing bumps as possible
Does not necessarily guarantee better results.
Depending on skin thickness, pore condition, elasticity, and pain sensitivity,
When manual injection is best
When DermaShine is best
When the Potenza pumping tip is more effective
I carefully distinguish these factors to recommend the optimal treatment method.
These days, with so many clinics offering low prices,
Many people choose a clinic based solely on price, thinking, ‘Should I just try Rejuran once?’
However, Rejuran is
👉 An exceptionally good treatment that is too precious to be administered carelessly.
I strongly recommend getting it done at a dermatology clinic with extensive treatment experience.
Rejuran Injection Methods
① Manual Injection (Embossing Injection)
Injected stitch by stitch, creating a **wheal (embossing)**
Effective for those with thin skin prone to fine lines
May be difficult for those with trypophobia
★ What is Rejuran Embossing?
Because Rejuran has large particles and high viscosity,
👉 The embossing is especially visible when injected at the epidermal-dermal junction.

For thin skin → Embossing is highly distinct
For thick, oily skin with large pores →
The solution may leak into the pores, resulting in almost no embossing
In such cases,
✔️ An injector device (DermaShine)
✔️ Potenza pumping tip
It is much better to use these to uniformly control the depth and spacing.
② DermaShine (Injector)
Enables uniform treatment with consistent depth and spacing
Less pain burden
Advantageous for improving overall facial balance
③ Potenza Pumping Tip
Fine microneedles + solution injection
Almost no bleeding or pain
Makeup can be applied from the next day
Covers pores, scars, skin texture, fine lines, and elasticity all at once
→ The most versatile all-rounder among Rejuran injection methods
💡 Important Point
Even if Rejuran enters the fat layer below the dermis,
Only the immediate effects are delayed;
Stem cell activation within the fat layer
Stimulation of surrounding dermal fibroblasts
Ensure that the long-term regenerative effects are not significantly different.
The Role of Rejuran
Pore improvement
Redness reduction
Skin barrier strengthening
(Most frequently recommended as a first treatment for those with atopy or dermatitis)
Elasticity improvement
Fine line reduction
Types of Rejuran
1️⃣ Rejuran Healer

The Original
Single ingredient: PN (Polynucleotide)
The main product that forms the foundation of skin regeneration
2️⃣ Rejuran HB

PN + Lidocaine (pain reduction) + HA (hydration)
Pain is less than half that of Rejuran Healer
Excellent for quick hydration and a dewy glow effect
✔️ Recommended 3–4cc for the full face
✔️ If ‘hydration is the most important,’ HB is recommended over Rejuran Healer
📌 Recommended Combination for Hydration
Belotero Revive → Rejuran HB → Aqua Shine Injection
3️⃣ Rejuran I (Eye)

Can be applied to the entire eye area including the eyelids, as well as around the mouth
The skin around the eyes is very thin, making a dedicated product essential
The eye area is exactly where aging, fine lines, and pigmentation begin first.
👉 Recommended Combination
Eye Thermage / Eye Density + Rejuran I + Skin Botox
If you have under-eye hollowness:
Deep layer: Eye Light
Shallow layer: Belotero Soft
If necessary: Combine with Jamber Eye
→ Reduces filler volume while extending longevity
❓ Is Rejuran more effective the more densely it is injected?
❌ Absolutely NO
Rejuran is not a treatment that only improves the injected area;
👉 It stimulates fibroblasts to improve the overall condition of the skin.
When the target area is clear, like the butterfly zone or scars → Focus
For full-face treatments →
Inject densely in the areas where you want the most effect,
And strategically distribute it to other areas. This is the key.
Rejuran Healer Full-Face Dosage
Usually 2 syringes = 4cc
If necessary, proceed with 6cc